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In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. A reaction with another antigout drug, allopurinol, may cause a rash. Unlike PURINETHOL (mercaptopurine) and IMURAN® (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. Allopurinol will help prevent gout attacks only as long as you continue to take it. Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIM® (allopurinol).

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